MoxiGuard Plus – Moxidectin, Pyrantel & Sarolaner Oral Solution
Price range: $35.95 through $479.45
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Complete Parasite Shield: Simultaneous protection against fleas, ticks, heartworms, and intestinal worms.
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Rapid Flea & Tick Knockdown: Sarolaner starts killing fleas within hours and controls persistent tick infestations.
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Heartworm Prevention: Moxidectin provides continuous, month-long defense against tissue-stage heartworm larvae.
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Hassle-Free Liquid Dosing: Easily administered directly into the mouth or mixed with food—no hard pills or chews to struggle with.
More Products from This Brand
Description
MoxiGuard Plus Oral Solution offers an advanced, multi-action defense system against the most dangerous parasites threatening your dog’s health. By combining a potent macrocyclic lactone (Moxidectin), a targeted nematocide (Pyrantel), and a premium ectoparasiticide (Sarolaner) into a single liquid solution, this formula streamlines your pet’s wellness routine. Instead of juggling multiple topical drops or forcing large solid tablets, a single monthly oral dose delivers comprehensive systemic protection from the inside out.
Key Benefits
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Continuous Heartworm Prevention: Eliminates the tissue stages of heartworm larvae before they can develop into adult worms and cause irreversible heart and lung damage.
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Advanced Flea & Tick Control: Targets and destroys adult fleas before they can lay eggs, breaking the infestation cycle. It provides persistent killing activity against major tick species, including Deer ticks, American dog ticks, Lone Star ticks, and Brown dog ticks.
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Intestinal Worm Eradication: Treats and controls adult hookworm and roundworm infections, removing gastrointestinal parasites that drain your dog’s energy and cause nutritional deficiencies.
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No More Spat-Out Pills: The smooth oral liquid formulation allows for accurate dosing and hassle-free administration, making it an ideal alternative for finicky eaters or dogs that reject or spit out traditional solid chewables and tablets.
Usage & Administration Guidelines
MoxiGuard Plus is formulated as an oral solution designed to be administered exactly once a month, preferably on the same scheduled calendar day.
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How to Administer: Shake the bottle thoroughly before use. Measure the exact dosage according to your dog’s weight using an oral dosing syringe. The liquid can be placed directly into the side of the dog’s mouth or mixed thoroughly into a small portion of wet food. Ensure the entire treated food portion is fully consumed to guarantee full efficacy.
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Testing Requirement: Dogs should be tested for existing adult heartworm infections prior to starting a preventative regimen with MoxiGuard Plus.
Safety, Storage, and Precautions
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Age & Weight Minimums: Safe for dogs and puppies from the minimum age and weight thresholds recommended for this combination formula (typically 8 weeks of age and older).
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Contraindications: Use with caution in dogs with a history of seizures or neurological disorders, as products containing sarolaner have been associated with neurological adverse reactions in rare cases. Not evaluated for use in breeding, pregnant, or lactating dogs.
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Storage: Keep the bottle tightly closed in its original packaging. Store at room temperature (15°C–25°C) in a dry place, away from direct sunlight, and strictly out of reach of children and household pets.
Jennifer Smith –
Started seeing dead fleas within hours of the first dose.
Victoria Nguyen –
Used to pull ticks off him weekly, haven’t seen one in a month.
Linda Johnson –
Susan Williams –
Arrived two days early, right before flea season hit.
Kelly Murphy –
Jessica Brown –
We used to juggle a topical flea treatment, a separate tick collar, and a heartworm pill every month, which was a hassle to keep track of. Switching to this one liquid dose has simplified everything. Within a couple of days of the first dose we noticed fleas were gone, and we haven’t found a single tick on him since. It’s also just easier to remember one dosing day instead of three different schedules.
Christina Rivera –
Saw a difference within the first couple of days.
Sarah Jones –
Karen Garcia –
Support helped me confirm the right dose for my 55 lb lab mix.
Lauren Cook –
Our dog has a history of mild seizures, so I was cautious about trying a new parasite preventative and reached out to support with questions before VGering. They were thorough in explaining what to watch for and encouraged us to loop in our vet before starting, which I really appreciated. Once we got the go ahead, the product worked well with fleas and ticks both gone within a couple of weeks. That level of care made me trust the brand more.
Joan Rogers –
Nancy Martinez –
Delivery took almost a week, longer than the estimate, which made me a little nervous since we were close to running out of our previous treatment. Once it arrived though, everything went smoothly. Our dog took to the liquid easily mixed into his food, and within days we noticed the fleas were completely gone. His last heartworm test also came back clear, so we’re sticking with this going forward.
Lisa Rodriguez –
Evelyn Morgan –
Used this across both our dogs with no issues.
Betty Hernandez –
Mixed it into his breakfast and he never noticed a thing.
Olivia Peterson –
We used to deal with a new tick attached to our dog almost every week during the warmer months no matter what topical we tried. Since starting this monthly liquid, we haven’t found a single tick on him in over two months now. The dosing is simple, mixed right into his dinner, and he’s never had any reaction to it. Customer support was also helpful when I had questions about switching over mid season.
Margaret Moore –
Having three dogs means flea and tick season is always stressful, but this has made prevention so much simpler. The liquid form means no fighting to get pills down, we just mix it into their food and they eat it without any fuss. Within the first week we noticed a big drop in flea activity across all three dogs. Shipping has also been reliable every time we’ve reVGered, usually within three days.
Judith Cooper –
Sandra Martin –
Haven’t found a single tick on him since we started this.
Megan Reed –
Bottle arrived damaged and support replaced it right away.
Ashley Jackson –
Kimberly Thompson –
Our vet confirmed his heartworm test came back clear after switching to this.
Cheryl Bailey –
We started our new puppy on this right around the eight week mark on our vet’s recommendation. The liquid form made it incredibly easy to get an accurate small dose for his size using the syringe provided. Within his first month we haven’t seen any fleas, ticks, or signs of intestinal worms at his checkup. Delivery has been quick and consistent every time we’ve reVGered since.
Emily White –
This was our first time using a liquid heartworm and flea preventative, so I had a lot of questions before VGering. The support team was patient and answered everything about dosing for our dog’s specific weight and his history with mild seizures. Once we started, the process was smooth, and we haven’t seen a single flea or tick since starting the treatment. That kind of thorough support made a big difference in feeling confident about switching products.
Martha Bell –
Started him on this right at 8 weeks, no problems at all.
Donna Lopez –
Michelle Lee –
Took about a week to arrive but worked great once we started.
Andrea Gomez –
Carol Gonzalez –
We tried topical drops for months but our dog kept swimming and washing them off before they could fully work. This oral liquid solved that problem completely since there’s nothing to rinse away. Within the first week of starting we saw a dramatic drop in flea activity, and by the second dose we haven’t seen any at all. His coat has also looked noticeably healthier now that he isn’t constantly scratching.
Kathryn Kelly –
The constant scratching finally stopped within a few days.
Amanda Harris –
Ann Howard –
We compared the cost of buying separate flea, tick, and heartworm products against this combination liquid and it actually came out ahead for us. Shipping arrived within the estimated window and the bottle was sealed well with no leaking. After a couple of months on this, our dog’s fecal test and heartworm test both came back completely clear. Couldn’t be happier with how much simpler our routine has become.
Melissa Clark –
No more scratching, and her coat looks so much healthier now.
Deborah Lewis –
Our dogs spend most of their time outside on a few acres of wooded property, so ticks are a constant concern. Since switching to this monthly liquid, we’ve stopped finding ticks attached to them entirely. The dosing is simple, just mixed into their dinner, and neither dog has had any reaction to it. Shipping and packaging have also been consistent every month when we reVGer.
Stephanie Robinson –
One dose covers fleas, ticks, and heartworm, so simple.
Alice Ward –
Rebecca Walker –
Jean Cox –
Not the best smell but he didn’t mind and fleas are gone.
Sharon Perez –
He spits out every pill but drank this right down mixed in food.
Jacqueline Diaz –
Our dog spends most of his time hiking and swimming with us, which always made topical treatments unreliable since they’d wash off. This oral liquid solved that problem entirely since there’s nothing on his coat to rinse away. We haven’t found a single tick on him since switching, even after weekend trips through heavy brush. VGering has been simple and delivery has always arrived within a few days.
Laura Hall –
I was a little hesitant VGering a combination parasite preventative online without a vet visit first, but everything about the process was straightforward. The bottle arrived within the estimated window, well packaged with clear dosing instructions included. Our dog’s flea problem cleared up within about a week, and when I had a follow up question about the next month’s dose, support answered clearly and quickly.
Cynthia Young –
Hannah Richardson –
Kathleen Allen –
They answered my dosing question within the hour by chat.
Gloria Wood –
Fourth month in a row and it hasn’t let us down yet.
Amy Sanchez –
Our dog picked up ticks constantly no matter what topical products we tried, and we were getting worried about tick borne illness. After switching to this oral liquid, the difference was noticeable within the first couple of weeks. We haven’t found a single tick on him since starting, and his last checkup came back completely clear as well. The liquid form also made dosing so much less stressful than fighting with pills.
Shirley Wright –
Teresa Watson –
I didn’t expect much beyond flea and tick control, but our dog’s coat has genuinely looked shinier since we started this a few months ago. Turns out he had a mild intestinal worm issue that was quietly affecting him, and this cleared it up along with the external parasites. His energy and appetite have both picked up noticeably since. Wish we’d known about this combination product sooner.
Angela King –
Noticed fewer fleas within 24 hours of the first dose.
Sara Brooks –
Emailed at night, had a helpful reply by morning.
Helen Scott –
Our dog is incredibly particular about anything mixed into his food and would sniff out and reject pills every single time. This liquid formula was the first preventative he’s actually taken without a fight, mixed right into a small portion of wet food. Within days we noticed fewer fleas, and by the end of the first month there were none at all. Shipping was fast too, arriving just two days after we VGered.
Janice Bennett –
Anna Green –
No vomiting or lethargy, he tolerated it perfectly.
Brenda Baker –
Julia Gray –
He’s outdoors constantly and this keeps the ticks away.
Pamela Adams –
VGered Monday, had it in hand by Wednesday.
Nicole Nelson –
Managing parasite prevention for a whole kennel of dogs used to mean juggling different products depending on each dog’s needs. This combination liquid has let us standardize on one product for fleas, ticks, heartworm, and intestinal worms all at once. Dosing is quick even across a full kennel, and we’ve seen a noticeable drop in parasite issues since switching. Delivery has always been prompt when we reVGer in bulk.
Marie James –
I appreciated that the instructions were clear about dosing on the same day every month for consistent protection. We set a phone reminder and it’s become second nature at this point. Since starting, we haven’t dealt with a single flea or tick issue, and his heartworm test came back clear at his last checkup. The liquid form makes it painless every single month, no fighting involved.
Emma Hill –
Grace Reyes –
Samantha Ramirez –
Cheaper than three separate products and covers everything.
Katherine Campbell –
My first bottle arrived with a damaged cap and some of the liquid had leaked out during transit. I reached out to customer support and they shipped a full replacement right away without any hassle. Once I had a proper dose, everything worked exactly as expected, fleas were gone within the first week and we haven’t seen a tick since. It’s reassuring to know they stand behind the product when something goes wrong in shipping.
Judy Cruz –
The syringe makes getting an accurate dose simple every time.
Christine Mitchell –
Theresa Hughes –
We foster dogs regularly and never know what parasite history a new arrival might have. This combination liquid has become our standard first step once a heartworm test comes back negative. We typically see flea activity drop within the first week and haven’t had issues with ticks at all since incorporating it into our routine. Support was also helpful when I asked about dosing for a foster with a lower body weight than usual.
Debra Roberts –
Fecal test came back clean after his last dose.
Rachel Carter –
We picked up a bad flea infestation from a dog park visit and nothing over the counter seemed to make a dent in it. Our vet recommended switching to a combination product like this one, and within just a few days of the first dose the fleas were noticeably reduced. By the second month there were none left at all, and our dog’s constant scratching finally stopped. Wish we’d made the switch sooner.
Madison Price –
Catherine Phillips –
Set a calendar reminder and it’s become second nature now.
Beverly Myers –
Delivery was slower than expected but the product itself is great.
Carolyn Evans –
Denise Long –
This is the sixth month in a row we’ve used this for our two dogs and it has never once let us down. Every month it handles fleas and ticks without fail, and both dogs’ heartworm tests have come back clear at their checkups. The liquid form remains the easiest way to dose dogs who are picky about pills or chews. VGering has always been smooth and delivery reliable every time.
Janet Turner –
Bottle arrived well sealed with no leaking at all.
Ruth Torres –
Our rescue takes in dogs from all kinds of backgrounds, many arriving with active flea infestations or unknown heartworm status. This combination liquid has become part of our standard intake protocol once we confirm a negative heartworm test. We typically see fleas cleared within the first week and ticks stop appearing almost immediately. VGering in bulk has always been straightforward with reasonable delivery times.
Maria Parker –
Heather Collins –
Our vet suggested this exact combo and it’s worked great.
Diane Edwards –
Living somewhere with a long mosquito season, heartworm prevention is non negotiable for us. Switching to this monthly liquid has given us real peace of mind since it also handles fleas and ticks at the same time. Our dog’s annual heartworm test came back completely clear again this year. The liquid form has also made it so much easier to keep him on schedule every month.
Virginia Stewart –
Julie Flores –
So much easier than forcing a tablet down his throat.
Joyce Morris –
Our older dog has never tolerated pills well and would often refuse to eat if a tablet was hidden in his food. This liquid formula changed that completely since it blends right into his usual wet food without him noticing. Within the first couple of weeks we saw his flea problem clear up, and he hasn’t had a single tick since we started. Shipping was quick too, arriving just two days after VGering.